Although other kits were available, Applied Biosystem's AmpFℓSTR^® and Promega's PowerPlex^® kits were the main kits used during the CODIS STR Standardization Project.

The CODIS STR Standardization Project identified thirteen core loci, together with amelogenin: 

The two manufacturers responded rapidly by developing new kits that included the thirteen core loci and amelogenin. The manufacturers involved the forensic science community in the beta testing of the kits, requested feedback, and responded to numerous suggested changes. The cooperation was mutually beneficial. The industry was able to develop technology that would be readily accepted by the community; the community enabled industry to build a robust technology tailored to forensic STR testing.

Applied Biosystems retooled AmpFℓSTR^® Profiler™ and developed AmpFℓSTR^® Profiler Plus™ and AmpFℓSTR^® COfiler™.

Applied Biosystems Profiler Plus	Applied Biosystems COfiler

The loci included in these Biosystems are: (highlighted loci are included in both kits)

The combination of these two kits allows laboratories to test all core loci; the overlapping loci serve as a quality control measure in the testing process.

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